Novel Coronavirus Outbreak Oct 1 - Oct 8 2021

Most recent articles (newest articles listed first)

Open access

‘We are all in the same boat’: How societal discontent affects intention to help during the COVID-19 pandemic

Elena RestaSilvana MulaConrad BaldnerDaniela Di SantoMaximilian AgostiniJocelyn J. BélangerBen GützkowJannis KreienkampGeorgios AbakoumkinJamilah Hanum Abdul KhaiyomVjollca AhmediHandan AkkasCarlos A. AlmenaraMohsin AttaSabahat Cigdem BagciSima BaselEdona Berisha KidaAllan B. I. BernardoNicholas R. ButtrickPhatthanakit ChobthamkitHoon-Seok ChoiMioara CristeaSara CsabaKaja DamnjanovićIvan DanyliukArobindu DashKaren M. DouglasVioleta EneaDaiane Gracieli FallerGavan J. FitzsimonsAlexandra GheorghiuÁngel GómezAli HamaidiaQing HanMai HelmyJoevarian HudiyanaBertus F. JeronimusDing-Yu JiangVeljko JovanovićZeljka KamenovAnna KendeShian-Ling KengTra Thi Thanh KieuYasin KocKamila KovyazinaInna KozytskaJoshua KrauseArie W. KruglanskiAnton KurapovMaja KutlacaNóra Anna LantosEdward P. LemayCokorda Bagus J. LesmanaWinnifred R. LouisAdrian LuedersNajma Iqbal MalikAnton P. MartinezKira O. McCabeJasmina MehulićMirra Noor MillaIdris MohammedErica MolinarioManuel MoyanoHayat MuhammadHamdi MulukSolomiia MyroniukReza NajafiClaudia F. NisaBoglárka NyúlPaul A. O'KeefeJose Javier Olivas OsunaEvgeny N. OsinJoonha ParkGennaro PicaAntonio PierroJonas H. ReesAnne Margit ReitsemaMarika RulloMichelle K. RyanAdil SamekinPekka SanttilaEdyta SasinBirga M. SchumpeHeyla A. SelimMichael Vicente StantonWolfgang StroebeSamiah SultanaRobbie M. SuttonEleftheria TseliouAkira UtsugiJolien A. van BreenCaspar J. van LissaKees van VeenMichelle R. van DellenAlexandra VázquezRobin WollastVictoria Wai-lan YeungSomayeh ZandIris Lav ŽeželjBang ZhengAndreas ZickClaudia ZúñigaN. Pontus Leander
Open access

SARS‐CoV‐2 spike protein harnesses SNX27‐mediated endocytic recycling pathway

Graphical Abstract

SARS-CoV-2 spike protein harnesses SNX27-mediated endocytic recycling pathway Issue 4, 2021

Proposed model showing SNX27 promotes intracellular trafficking of S protein and viral production. (a) SNX27, via its PDZ domain, interacts with S protein and promotes endosome-to-plasma membrane trafficking of S protein. SNX27 could also promote the production of SARS-CoV-2 virions in host cells, although the mechanism remains poorly defined.

(b) Depletion of SNX27 impairs endosome-to-plasma membrane trafficking of S protein, leading to its lysosomal degradation.

Open access

Bioequivalence and food effect of a fixed‐dose combination of macitentan and tadalafil: Adaptive design in the COVID‐19 pandemic

Graphical Abstract

Bioequivalence and food effect of a fixed-dose combination of macitentan and tadalafil: Adaptive design in the COVID-19 pandemic Issue 5, 2021

The macitentan 10 mg/tadalafil 40 mg Fixed Dose Combination is bioequivalent to the free combination. No clinically significant differences in PK were determined between fed and fasted conditions of the FDC formulation.

Open access

Lung squamous cell carcinoma with hemoptysis after vaccination with tozinameran (BNT162b2, Pfizer-BioNTech)

Graphical Abstract

Lung squamous cell carcinoma with hemoptysis after vaccination with tozinameran (BNT162b2, Pfizer-BioNTech) Issue 22, 2021

Patients in conditions such as after chemoradiation, especially in patients with radiation pneumonitis wherein the vasculature is vulnerable, should be carefully monitored for hemorrhagic events after vaccination.

Open access

Severe hypertransaminasemia during mild SARS‐CoV‐2 infection: A pediatric case report and literature review

Graphical Abstract

Severe hypertransaminasemia during mild SARS-CoV-2 infection: A pediatric case report and literature review Issue 4, 2021

Liver injury during SARS-CoV-2 infection has a multifactorial pathogenesis. We describe a pediatric case with severe increase of serum aminotransferases in the course of mild SARS-Cov-2 infection.

Open access

Seasonal UV exposure and vitamin D: association with the dynamics of COVID‐19 transmission in Europe

Graphical Abstract

Seasonal UV exposure and vitamin D: association with the dynamics of COVID-19 transmission in Europe Issue 1, 2022

We observed a strong correlation of UV exposure with COVID-19 incidences for 26 European countries. Exposure–lag–response association analysis revealed that UV exposure had a significant delayed effect on COVID-19 incidences. Meta-analysis of vitamin D levels in COVID-19 suggests that low vitamin D level is a critical risk factor for COVID-19. In conclusion, low UV exposure could affect the required vitamin D production in the body, which substantially impacts COVID-19 transmission.

Open access

Assessment of antiphospholipid antibodies and calprotectin as biomarkers for discriminating mild from severe COVID‐19

Graphical Abstract

Assessment of antiphospholipid antibodies and calprotectin as biomarkers for discriminating mild from severe COVID-19 Issue 11, 2021

Multiple comparison of receiver operating characteristic (ROC) curve evaluation for the performance of laboratory parameters. (A) ROC curves for discriminating between R1 and R2 groups. (B) ROC curves for discriminating between ARDS− and ARDS+ groups. Multiple comparison of the discriminatory performance of calprotectin with other laboratory parameters between mild and severe groups in the patients with COVID-19. This research revealed that calprotectin's performance surpassed other parameters' performances in predicting COVID-19 severity. Therefore, we suggest that serum calprotectin is a potentially valuable biomarker for predicting the clinical severity of COVID-19, independently or in combination with other conventional parameters. Calprotectin and CRP levels were measured in this research. Lymphocyte count, neutrophil count, NLR and CD4+ T cells count were obtained from the hospital's electronic medical records, in which the data for each parameter was selected within 48 h from the research sample collection time (n = 85). CRP, C-reactive protein; NLR, neutrophil-to-lymphocyte ratio; ARDS, acute respiratory distress syndrome.

full access

A Modular Biomaterial Scaffold‐Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS‐CoV‐2 Antigens

Graphical Abstract

A Modular Biomaterial Scaffold-Based Vaccine Elicits Durable Adaptive Immunity to Subunit SARS-CoV-2 Antigens Issue 22, 2021

Mesoporous silica rods (MSRs) scaffolds are used as a platform to induce adaptive immunity against SARS-CoV-2 antigens. Sustained delivery of GM-CSF, MPLA, and a variety of SARS-CoV-2 subunit immunogens from the MSR vaccine recruite immune cells into the scaffolds and consistently induce antigen-specific long-lasting antibodies, cytotoxic T lymphocyte responses (CTL), and viral neutralization in vitro.

Open access

Subacute thyroiditis following COVID‐19 vaccination

Graphical Abstract

Subacute thyroiditis following COVID-19 vaccination Issue 10, 2021

Physicians should be alert about the possibility of subacute thyroiditis (SAT) being induced by COVID-19 vaccination. SAT may present with anterior neck pain, extended fever or palpitation in recently vaccinated patients, which should not be easily dismissed as expected post-vaccination flu-like symptoms, thereby, facilitating in time diagnosis and treatment.

Open access

Multidisciplinary approach to a septic COVID‐19 patient undergoing veno‐venous extracorporeal membrane oxygenation and receiving thoracic surgery

Graphical Abstract

Multidisciplinary approach to a septic COVID-19 patient undergoing veno-venous extracorporeal membrane oxygenation and receiving thoracic surgery Issue 10, 2021

A multidisciplinary approach appears to be fundamental for the treatment of critically ill patients with COVID-19, improving clinical outcomes, even in the most severe cases. Such severe cases are advisable to be collegially discussed between intensivists, surgeons, infectious disease, and other physicians potentially involved.

Open access

Herpes‐like skin lesion after AstraZeneca vaccination for COVID‐19: A case report

Graphical Abstract

Herpes-like skin lesion after AstraZeneca vaccination for COVID-19: A case report Issue 10, 2021

Recurrent herpes simplex virus or varicella zoster virus infection should be considered as one of the rare complications after AstraZeneca vaccination for COVID-19.

Open access

First report of invasive Aspergillus rhinosinusitis in a critically ill COVID-19 patient affected by acute myeloid leukemia, northeastern Iran

Graphical Abstract

First report of invasive Aspergillus rhinosinusitis in a critically ill COVID-19 patient affected by acute myeloid leukemia, northeastern Iran Issue 10, 2021

This is a report of established invasive Aspergillus rhinosinusitis in a patient diagnosed with COVID-19 and afflicted by AML, which was initially considered to be rhinocerebral mucormycosis.

Open access

CT patterns and differential criteria for acute eosinophilic pneumonia and COVID‐19 pneumonia

Graphical Abstract

CT patterns and differential criteria for acute eosinophilic pneumonia and COVID-19 pneumonia Issue 10, 2021

Computed tomography semiotics are even important together with laboratory data and clinical currents to establish a diagnosis between acute eosinophilic pneumonia and coronavirus disease pneumonia.

Open access

COVID‐19 outbreak as a probable cause of increased risk of intracranial rebleeding in partially treated cerebral arteriovenous malformations

Graphical Abstract

COVID-19 outbreak as a probable cause of increased risk of intracranial rebleeding in partially treated cerebral arteriovenous malformations Issue 10, 2021

Patients who are infected with COVID-19 and have cerebral arteriovenous malformations which are partially treated or untreated may be more liable to rupture or bleed than not infected patients.

Open access

A man with an alcoholic‐related duodenal perforation after losing his job due to the SARS‐COV‐2 pandemic

Graphical Abstract

A man with an alcoholic-related duodenal perforation after losing his job due to the SARS-COV-2 pandemic Issue 10, 2021

Pneumoperitoneum is a medical emergency, which should be diagnosed quickly using an X-ray. Public health crisis can impact physical health to varying degrees across socioeconomic groups. A clear social history can guide differential diagnosis.

Open access

Lichenoid cutaneous skin eruption and associated systemic inflammatory response following Pfizer-BioNTech mRNA COVID-19 vaccine administration

Graphical Abstract

Lichenoid cutaneous skin eruption and associated systemic inflammatory response following Pfizer-BioNTech mRNA COVID-19 vaccine administration Issue 11, 2021

This is a report of a case of generalized lichenoid skin eruptions and systemic inflammatory response occurring together following the first dose of the Pfizer-BioNTech vaccine. This case adds to an accumulating body of literature connecting autoimmunity with the pathophysiology of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Open access

A case of massive saddle pulmonary embolism and benign tracheal stenosis in a patient with COVID-19 infection

Graphical Abstract

A case of massive saddle pulmonary embolism and benign tracheal stenosis in a patient with COVID-19 infection Issue 11, 2021

We report the case of a patient with a recent coronavirus disease 2019 (COVID-19) infection that got complicated by a massive pulmonary embolism as well as benign post-intubation tracheal stenosis.

Open access

Characterization of SARS‐CoV‐2 and common cold coronavirus‐specific T‐cell responses in MIS‐C and Kawasaki disease children

Graphical Abstract

Characterization of SARS-CoV-2 and common cold coronavirus-specific T-cell responses in MIS-C and Kawasaki disease children Issue 1, 2022

T cells derived from children with multisystem inflammatory syndrome (MIS-C) respond to SARS-CoV-2 spike and nonspike peptide megapools. SARS-CoV-2-specific memory T cells and homing receptors showed different patterns between CD4+ and CD8+ T cells. MIS-C subjects had very low myeloid dendritic cells in circulation including ILT-4+ CD4+ tolerogenic dendritic cells.

Open access

Establishing an internal quality control method for the stable extraction of nucleic acids of severe acute respiratory syndrome coronavirus 2 and RT‐PCR‐based detection

Graphical Abstract

Establishing an internal quality control method for the stable extraction of nucleic acids of severe acute respiratory syndrome coronavirus 2 and RT-PCR-based detection Issue 11, 2021

Real-time RT-PCR is used in many countries to detect SARS-CoV-2; however, there is no standardized method for quality control during RT-PCR-based detection. Our study showed that the use of a quality control substance (EAV) and quality control charts ensures internal quality control for the extraction of SARS-CoV-2 nucleic acid and the subsequent virus detection.

full access

Turn Up the Lights, Leave them On and Shine them All Around—Numerical Simulations Point the Way to more Efficient Use of Far‐UVC Lights for the Inactivation of Airborne Coronavirus

Graphical Abstract

Turn Up the Lights, Leave them On and Shine them All Around—Numerical Simulations Point the Way to more Efficient Use of Far-UVC Lights for the Inactivation of Airborne Coronavirus Issue 2, 2022

Trajectories from computer simulations showing inactivation of virus particles as they pass under Far-UVC germicidal lights in a classroom-sized environment with mechanical ventilation incoming from the right hand side and three cracked-open windows on the left.