Covid-19: Novel Coronavirus Outbreak

DKA as an early manifestation of monogenic diabetes (eg, Wolcott-Rallison syndrome) in infancy, can be accelerated by COVID-19 infection, so its distinction is imperative in clinical settings.

In this study, we report a case of a 16-year-old female patient who is a known case of systemic lupus erythematosus (SLE) for 5 months and is on steroids presenting with hypocalcemia and massive pulmonary embolism diagnosed clinically while she has COVID.

Think zinc! We conjecture that in the case of SARS-CoV-2, the orf7a accessory protein acts as a BST2 antagonist. We provide evidence, based on sequence analysis, Molecular Dynamics simulations as well as XAS experiments, that Zn ions play a key role in the SARS-CoV-2 virus strategy to escape the immune response mediated by the BST2 host protein.

Computational method-based systematic analysis that can optimize the carbon nanotube (CNT) thin-film properties and sensitivity of immunosensors is utilized, potentially enabling mass manufacturing of point-of-care biosensor for accurate and rapid diagnosis of various diseases. Using CNT films with high alignment and low roughness, nucleocapsid protein in SARS-CoV-2 virus is detected with a sensitivity of 0.048 [copies/mL]⁻¹.

As public COVID-19 vaccination programs are being implemented, it is possible that more rare and serious adverse effects such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) may occur

Animal models that recapitulate characteristics and immune responses observed in COVID-19 patients are urgently needed. These animal models such as mouse, hamster, nonhuman primate, and ferret, have provided robust platforms for studying the transmission, pathogenesis, and immunology induced by SARS-CoV-2, and for evaluating the immunomodulatory and antiviral drugs and vaccines against COVID-19.

This correspondence discussed on published article on “Prevalence and risk factors for gastrointestinal symptoms after recovery from COVID-19.” Effect of confounding factor is possible. Regardless of COVID-19, clinical problem might be due to other cause.

We have identified novel interactors of the SARS-CoV-2 nucleocapsid (NCAP) protein in human lung epithelial cancer cells. NCAP showed specific interaction with the stress granule (SG) proteins G3BP1, G3BP2, YTHDF3, USP10 and PKR, and translocated to SGs following stress treatments. NCAP exhibited RNA-dependent phase separation. The RNA intercalator mitoxantrone disrupted NCAP assembly in vitro and in cells. This study provides insight into the biological processes and biophysical properties of the NCAP.

The authors report an improved low-cost manufacturing process in yeast for a component of a clinical-stage COVID-19 vaccine candidate. An engineered strain of Pichia pastoris produces the antigen without using methanol, improving the secreted protein titer and cell health. Elimination of methanol as a process requirement enabled rapid technology transfer to an existing large-scale production facility.

A semiconductor device process design thread is achieved in the course by integrating the laboratory experience and process simulation/modeling and theoretical calculations. The risks associated with the COVID-19 pandemic have forced significant course modifications in both lecture and laboratory components. A remote learning format and video-based laboratory sessions could provide students seamless experiences and learning.

The author discusses the complex ethical issues faced by transplant center leaders in contemplating the institution of a vaccine mandate for actively waitlisted kidney transplant candidates. Silverstein comments on page 335.